Sugar Spheres, Compressible Sugar, Confectioner’s Sugar Manufacturers, with SDS. The model provides support for further research into powder properties and tablet preparation.Endstreamendobj45 0 objstream The following points outline certain aspects where the two concepts differ, to make it easier for the user to decide which one to choose: Why should you decide to use pharm-a-spheres™ sugar spheres? Pellets are a multiparticle, solid form of medication. Therefore, the newly established model is reliable for evaluating both the compressibility and the compactibility of powders.
Supertab 24an verification#
The results of model experiments ( r = 0.767, 0.895, and 0.756), literature, and repeatability verification demonstrated that the main parameters y 0 and b in the established model have good applicability and repeatability.
![supertab 24an supertab 24an](http://mdxyyfl.com/home/b/1/lrqirx/resource/2019/12/05/5de86303bd591.jpg)
b has a strong correlation with the evaluation parameter of material compactibility, such as the slope of the tensile strength versus compaction force ( k A, r = 0.780, P < 0.01) and the tensile strength versus porosity (Ryshkewitch-Duckworth equation) ( k R, r = 0.658, P < 0.01). The results show that y 0 has a strong correlation with the mean yield pressure (Py, r = 0.609, P < 0.01), which is the evaluation parameter of material compressibility.
![supertab 24an supertab 24an](http://www.scielo.org.mx/img/revistas/rmcf/v46n2/1870-0195-rmcf-46-02-00041-gf5.png)
The physical meaning of y 0 and b were studied in the model.
![supertab 24an supertab 24an](http://www.scielo.org.mx/img/revistas/rmcf/v46n2/1870-0195-rmcf-46-02-00041-gf3.png)
The model was established as CR = y 0 + Ae − bP, r 2 ≥ 0.9684 (where CR is the compression ratio and P is the compaction force and y 0, A, b is constant). Eighteen types of pharmaceutical excipients were studied via direct compaction. The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously.